Authors: Cuspidi, Cesare; Sala, Carla; Zanchetti, Alberto

Source: Expert Review of Cardiovascular Therapy, Volume 6, Number 5, June 2008 , pp. 731-743(13)

Publisher: Expert Reviews

Abstract:

A growing body of evidence indicates that the clustering of metabolic and hemodynamic abnormalities characterizing the metabolic syndrome is associated with a prevalence of subclinical damage in a variety of organs, such as left ventricular hypertrophy, thickening or atherosclerotic plaques of carotid arteries, microalbuminuria and deranged renal function. This is clinically relevant since these markers of target organ damage are associated with an increased risk of cardiovascular fatal and nonfatal events. The contribution of the metabolic syndrome to target organ damage in hypertensives is presumably responsible for a substantial increase in cardiovascular fatal and nonfatal events. Thus, target organ damage should be routinely searched for in hypertensives with metabolic syndrome in order to define initial therapeutic strategies and to monitor treatment-induced protection.

Keywords: carotid atherosclerosis; hypertension; left ventricular hypertrophy; metabolic syndrome; microalbuminuria

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14779072.6.5.731

Affiliations: 1: Associate Professor of Internal Medicine, Chief of Clinical Research Unit, Istituto Auxologico Italiano, Clinical Research Unit, Via della Resistenza 23, 20036 Meda, (Mi), Italy., Email: cesare.cuspidi@unimib.it

Publication date: 2008-06-01

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• Expert Review of Cardiovascular Therapy provides expert commentary on the clinical applications of the new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage inculdes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery.
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