Authors: Kiechl, Stefan; Werner, Philipp; Knoflach, Michael; Furtner, Martin; Willeit, Johann; Schett, Georg

Source: Expert Review of Cardiovascular Therapy, Volume 4, Number 6, November 2006 , pp. 801-811(11)

Publisher: Expert Reviews

Abstract:

Owing to the common coincidence of osteoporosis and vascular disease, pathophysiological links between both disorders have long been sought. The osteoprotegerin (OPG)/receptor activator of NF-κB (RANK)/receptor activator of NF-κB ligand (RANKL) cytokine network, a key regulatory system in bone homeostasis, has been implicated recently in vascular calcification, changes in matrix composition and diabetic macroangiopathy, aortic aneurysm development, heart failure and, most importantly, advanced atherosclerosis, plaque destabilization and manifestation of cardiovascular diseases. The concept of an active role of RANKL and OPG in vascular pathophysiology is intriguing and is gaining increasing support from both epidemiological and basic research. OPG serum level is considered to be a stable and reliable indicator of the overall activity of the OPG/RANK/RANKL axis and may find application as a biomarker of vascular risk and prognosis. RANKL in turn may be a suitable target for novel therapies. Pharmacological strategies for specific interference with the OPG/RANK/RANKL axis are currently being developed and evaluated in osteoporosis therapy.

Keywords: aortic aneurysm; atherosclerosis; calcification; cardiovascular disease; heart failure; inflammation; osteoporosis; osteoprotegerin; RANKL

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14779072.4.6.801

Publication date: 2006-11-01

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• Expert Review of Cardiovascular Therapy provides expert commentary on the clinical applications of the new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage inculdes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery.
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