Notch signaling in lung cancer

Authors: Galluzzo, Paola; Bocchetta, Maurizio

Source: Expert Review of Anticancer Therapy, Volume 11, Number 4, April 2011 , pp. 533-540(8)

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Abstract:

Lung cancer is the leading cause of cancer-related deaths in the Western world. The lungs can be affected by a number of histologically diverse malignancies. Nonetheless, the vast majority of lung cancers are classified as non-small-cell lung cancer (NSCLC). Despite extensive research on different therapeutic regimens, the overall 5-year survival of patients diagnosed with NSCLC (all stages) is a dismal 15%. Although strongly correlated with tobacco smoke, there is an increasing NSCLC morbidity in individuals who have never smoked. The pattern of genetic lesions found in NSCLC derived from smokers and never-smokers appears to be different. This fact led to the hypothesis that different, still unidentified carcinogens are responsible for lung cancer onset in never-smokers. All the aforementioned considerations compel the scientific community to find novel therapeutic targets to fight such a deadly disease. In recent years critical pathways governing embryonic development have been increasingly linked to cancer. Here we will focus on the role of Notch signaling in lung cancer. Notch receptors'' activity can be blocked through the use of different strategies, thus representing a promising alternative/complement to the arsenal of therapeutic strategies currently used to treat lung cancer.

Keywords: cancer progenitor cells; cancer stem cells; hypoxia; lung cancer; Notch signaling; Notch signaling inhibition

Document Type: Research article

DOI: http://dx.doi.org/10.1586/era.10.158

Affiliations: 1: 1Loyola University Chicago Medical Center, Department of Pathology and Oncology Institute, 2160 South First Avenue, Maywood, IL 60153, USA

Publication date: 2011-04-01

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Notch signaling in lung cancer

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