Structural and functional analysis of human prostatic acid phosphatase

Authors: Hassan, Md Imtaiyaz; Aijaz, Afnan; Ahmad, Faizan

Source: Expert Review of Anticancer Therapy, Volume 10, Number 7, July 2010 , pp. 1055-1068(14)

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Abstract:

Prostatic acid phosphatase (PAP) is the most abundant phosphatase in human prostate tissue/secretions. It is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. We describe here most of the features of PAP including gene regulation, gene/protein structure, functions, its role in tumor progression and evolutionary features. PAP has phosphatase activity and is an extensively studied biomarker of prostate cancer. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His¹² and Asp²⁵⁸) that are located in the cleft between two domains. This article will be of great interest to all those scientists who are working in the area of prostate pathophysiology.

Keywords: androgen receptor; benign prostatic hyperplasia; biomarker; breast carcinoma; fertilization; prostate cancer; prostatic acid phosphatase

Document Type: Research article

DOI: http://dx.doi.org/10.1586/era.10.46

Affiliations: 1: 1Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India

Publication date: 2010-07-01

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