Gene therapy for superficial bladder cancer

Authors: Rosser, Charles J; Benedict, William F; Dinney, Colin PN

Source: Expert Review of Anticancer Therapy, Volume 1, Number 4, December 2001 , pp. 531-540(10)

Publisher: Expert Reviews

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Abstract:

In this review, the basics of gene therapy and the strategies to increase the therapeutic effect of gene therapy for superficial bladder cancer are discussed. Strategies considered in detail are modification of the structure of vectors, modification of the promoters of viral vectors and the timing and route of vector administration. Although all of these modifications have shown some degree of improvement for gene transfer, the use of polyamides intravesically in conjunction with an adenoviral system shows the most promise and the greatest potential to supplement or even replace the current treatment modalities for superficial bladder cancer.

Keywords: adenovirus; gene therapy; polyamides; superficial bladder cancer

Document Type: Research article

DOI: 10.1586/14737140.1.4.531

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