Proteomic analysis of renal diseases: unraveling the pathophysiology and biomarker discovery

Author: Thongboonkerd, Visith

Source: Expert Review of Proteomics, Volume 2, Number 3, June 2005 , pp. 349-366(18)

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Abstract:

Current biomedical applications of proteomics have been conducted with four main objectives: to better understand the normal biology and physiology of cells, microorganisms, tissues and organs; to explore the pathogenic mechanisms and better understand the pathophysiology of medical diseases; to identify novel biomarkers for early disease detection, prediction and prognosis; and to define new therapeutic targets, drugs and vaccines. This review focuses predominantly on proteomic applications to unravel the pathophysiology and to define novel biomarkers for various renal diseases (i.e., glomerular diseases, tubulointerstitial diseases, renal vascular disorders and renal cancers). In addition, proteomic evaluations of renal transplantation and renal replacement therapy (for acute renal failure and end-stage renal disease) are summarized. Personal opinion, future perspectives and information resources for the field of renal and urinary proteomics are provided.

Keywords: alternative approach; biomarkers; classic approach; kidney; nephrology; pathophysiology; proteome; proteomics; renal diseases; subproteome; targeted proteomics; urine

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14789450.2.3.349

Publication date: 2005-06-01

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Expert Review of Proteomics explores technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease.
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