Proteomics-on-a-chip:the cahllenge to couple lab-on-a-chip unit operations

Author: Schasfoort, Richard BM

Source: Expert Review of Proteomics, Volume 1, Number 1, June 2004 , pp. 123-132(10)

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Abstract:

This review describes a vision of a proteomics-on-a-chip device to separate, detect and identify the proteome. It guides the reader towards a development strategy, avoiding some of the pitfalls. It also describes the current state-of-the-art developments in proteomic analysis including available technologies, current market issues, the elements of an envisaged proteomics-on-a-chip device, the required microfabrication processes and the integration of the elements into one device. Address-flow microfluidics is a tool for connecting separation and detection platforms. The final section contains an expert opinion on the recommended development strategies, benefits of proteomics-on-a-chip in the life sciences and the anticipated market.

Keywords: biomolecular interaction; capillary electrophoresis; lab-on-a-chip; mass spectrometry; microfluidics; proteome; surface plasmon resonance

Document Type: Research article

DOI: http://dx.doi.org/10.1586/14789450.1.1.123

Publication date: 2004-06-01

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Expert Review of Proteomics explores technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease.
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