Candida chorioretinitis and endophthalmitis

Authors: Gerstenblith, Adam T; Shah, Chirag P

Source: Expert Review of Ophthalmology, Volume 4, Number 2, April 2009 , pp. 187-196(10)

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Abstract:

Ocular candidiasis is a common cause of endogenous fungal endophthalmitis and can also occur in the postoperative setting. The diagnosis of ocular candidiasis is usually made on clinical grounds but microbiological cultures are helpful to establish the identity of the infecting organism and determine the antimicrobial sensitivities. It is likely that PCR technology will become more important in the near future for rapid identification of infecting organisms, as it is applicable to both anterior chamber fluid and vitreous sampling. Furthermore, PCR has the potential to assist in directing antifungal therapy. There are many different antifungal agents in clinical use. Recent studies of newer antifungals, such as voriconazole, show significant potential for their use in the treatment of intraocular infections. Vitrectomy may provide benefit in cases presenting with severe vitritis at presentation or in cases with mild vitritis unresponsive to medical therapy.

Keywords: amphotericin B; Candida; candidiasis; caspofungin; chorioretinitis; endophthalmitis; fluconazole; fungal; fungus; ocular; vitrectomy; vitritis; voriconazole

Document Type: Research article

DOI: http://dx.doi.org/10.1586/eop.09.11

Affiliations: 1: Retina Service, Wills Eye Institute, 840 Walnut Street, Suite 1020, Philadelphia, PA 19107, USA

Publication date: 2009-04-01

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