Brinzolamide/timolol fixed combination for open-angle glaucoma and ocular hypertension

Author: Holló, Gábor

Source: Expert Review of Ophthalmology, Volume 4, Number 2, April 2009 , pp. 129-133(5)

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Abstract:

The brinzolamide/timolol fixed combination contains brinzolamide 1% and timolol maleate 0.5% in ophthalmic suspension produced for twice-daily application to reduce elevated intraocular pressure in open-angle glaucoma and ocular hypertension. This fixed combination was recently approved by the European Medicines Agency, in December 2008. The brimzolamide/timolol fixed combination provides an approximately 30-33% intraocular pressure reduction from the untreated baseline of 25-27 mmHg, thus is more potent than any of its ingredients alone and is similarly effective but better tolerated than the dorzolamide/timolol fixed combination, which consists of molecules from the same drug classes. The fixed combination of brinzolamide and timolol can be used as a separate therapy, but due to the additivity of its ingredients to drugs belonging to other classes, it may also be administered in combination with other intraocular pressure-lowering molecules, most importantly topical prostaglandin analogues.

Keywords: brinzolamide/timolol fixed combination; ocular hypertension; open-angle glaucoma; ophthalmic suspension

Document Type: Research article

DOI: http://dx.doi.org/10.1586/eop.09.7

Affiliations: 1: Department of Ophthalmology, Semmelweis University, 1083. Budapest, Tömö u. 25-29, Hungary., Email: hg@szem1.sote.hu

Publication date: 2009-04-01

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