Authors: Teus, Miguel A; Arranz-Marquez, Esther

Source: Expert Review of Ophthalmology, Volume 3, Number 2, April 2008 , pp. 203-209(7)

Publisher: Expert Reviews

Abstract:

Prostaglandin F2α analogues are the most recent class of ocular hypotensive drugs that have become available for clinical use in patients with glaucoma. The terms `prostanoids' and `prostaglandin analogues' have been used to identify a group of compounds that are structural analogues of naturally occurring prostaglandin F2α; however, each drug has a different molecular structure that confers slightly different properties. The introduction of this group of antiglaucomatous drugs represented a revolution in glaucoma treatment not only as a result of their novel mechanism of action, but also due to the potent ocular hypotensive effect. Most prostaglandin F2α analogues are considered to be a first-line treatment for glaucoma. Although prostaglandin F2α analogues have a low incidence of systemic side effects (in contrast to those reported for other antiglaucomatous medications), their use has been associated with local adverse effects, including a novel intriguing side effect: prostaglandin-induced increased iridial pigmentation.

Keywords: bimatoprost; drug; glaucoma; hypotensive; increased intraocular pressure; latanoprost; PF2α analogues; prostaglandin analogues; prostanoids; travoprost; unoprostone

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17469899.3.2.203

Affiliations: 1: Vissum Madrid; Head of the Ophthalmology Department, Hospital Universitario Principe de Asturias, Alcalá de Henares, Madrid, Spain; and, Full Professor of Ophthalmology, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain., Email: mteus@vissum.com

Publication date: 2008-04-01

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