Advances in the topical ocular drug delivery

Authors: Sultana, Yasmin; Aqil, M; Ali, Asgar; Samad, Abdus

Source: Expert Review of Ophthalmology, Volume 2, Number 2, April 2007 , pp. 309-323(15)

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Abstract:

Technology for delivering active moieties to the eye has shown many advancements in recent years, from primitive eye drops to iontophoretic drug delivery, in situ gelling systems, dendrimers, penetration enhancers, lipid emulsions, ocular inserts, mucoadhesive polymers, thiolated polymers, collagen shield, soft drugs and site-specific drug delivery systems. The drawbacks of conventional therapy are largely circumvented by these advanced ocular drug delivery systems. However, so far, very few drug delivery systems have made their way to the market. Nevertheless, there has been extensive progress in the development of ocular delivery systems.

Keywords: collagen shields; dendrimers; in situ gelling systems; lipid emulsions; lyophilisates; microemulsions; mucoadhesive polymers; ocular drug delivery; ocular inserts; ocular iontophoresis; prodrugs; soft drugs; thiolated polymers; vesicular systems

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17469899.2.2.309

Publication date: 2007-04-01

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Expert Review of Ophthalmology provides an important platform for commentary and debate on current and emerging approaches in ocular medicine.
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