Is `scarless wound healing' applicable to glaucoma surgery?

Authors: Bruno, Christina A; Fisher, Gary J; Moroi, Sayoko E

Source: Expert Review of Ophthalmology, Volume 2, Number 1, February 2007 , pp. 79-90(12)

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Abstract:

The `simple' problem of fibrosis has a diverse public health impact ranging from disfiguring scarring, fibrosis of organs, visceral adhesions, mobility restriction and blindness. Both lay people and clinicians clearly recognize the phenotypic variation of cutaneous surgical outcomes ranging from keloids, hypertrophic scars, `normal' scar formation and `scarless' wound healing. By comparing the three major wound healing processes of inflammation, angiogenesis and fibrosis in the fetal and postnatal periods, clear differences are apparent in all three of these wound healing processes. The purpose of this review is to examine the current understanding of scarless wound healing and then to provide a perspective on the potential future application of these concepts to improve glaucoma filtration surgery outcomes.

Keywords: fibrosis; glaucoma; scarless wound healing; surgical outcome; trabeculectomy; wound healing

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17469899.2.1.79

Publication date: 2007-02-01

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