Historical considerations in applying vital dyes in vitreoretinal surgery: from early experiments to advanced chromovitrectomy

Authors: Meyer, Carsten H; A Oechsler, Rafael; Rodrigues, Eduardo B

Source: Expert Review of Ophthalmology, Volume 2, Number 1, February 2007 , pp. 71-77(7)

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Abstract:

This review describes the chronological development of different approaches to applying vital dyes in vitreoretinal surgery and the clinical implications of these developments. Previous experimental studies explored the intravenous, subretinal and intravitreal application of vital dyes. Since the year 2000, numerous dyes have been introduced for the recognition of thin semitransparent preretinal tissues during vitrectomy, a procedure known as chromovitrectomy. Recently, a novel instrument in a painting brush style, the Vitreoretinal INternal limiting membrane Colour Enhancer (VINCE), has become available for chromovitrectomy. Currently, there are six vital stains under evaluation for application during chromovitrectomy. Much of the animal research available, particularly on indocyanine green, indicates dose-dependent damage on the retinal tissue. Based on such observations, surgeons should use minimal concentrations and volume of intravitreous stains and the current trend is towards painting the retina rather than injection.

Keywords: chromovitrectomy; indocyanine green; retina; staining; vital dye

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17469899.2.1.71

Publication date: 2007-02-01

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