Genetic and modifiable risk factors for age-related macular degeneration

Author: Wang, Jie Jin

Source: Expert Review of Ophthalmology, Volume 1, Number 2, December 2006 , pp. 181-194(14)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

Age-related macular degeneration (AMD) is a leading cause of blindness in older people. Research into AMD genes has had a major breakthrough recently with the identification of a number of gene loci and single nucleotide polymorphisms that are strongly associated with AMD susceptibility. These include variants in the complement factor H, LOC387715, factor B and complement component 2 genes. Research on AMD risk factors has led to identification of a few consistent, modifiable risk factors (smoking) and protective factors (fish and antioxidant intake). A number of risk factors (light exposure, cataract surgery, inflammatory processes and cardiovascular-related pathogenic factors) deserve further investigation. Understanding the interactions between genetic susceptibility and environmental triggers is likely to be key in unraveling the pathogenesis of AMD. Lifestyle modifications, including smoking cessation and healthy diet changes, provide evidence-based, feasible preventive actions for older individuals susceptible to AMD.

Keywords: age-related macular degeneration; complement factor H; gene polymorphism; genetic susceptibility; modifiable risk factors; smoking

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17469899.1.2.181

Publication date: 2006-12-01

More about this publication?

Expert Review of Ophthalmology provides an important platform for commentary and debate on current and emerging approaches in ocular medicine.
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
Free Trials
ingentaconnect is not responsible for the content or availability of external websites