PI3K signaling: a crossroads of metabolic regulation

Authors: Braccini, Laura; Ciraolo, Elisa; Morello, Fulvio; Lu, Xiaoyun; Hirsch, Emilio

Source: Expert Review of Endocrinology and Metabolism, Volume 4, Number 4, July 2009 , pp. 349-357(9)

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Abstract:

Insulin exerts a fundamental role in glucose metabolism. Several lines of evidence have established PI3Ks as crucial signaling crossroads of metabolic regulation. These kinases play a key role in glucose homeostasis through the generation of lipid secondary messengers upon membrane receptor activation, thus regulating liver gluconeogenesis and glycogen synthesis. While class IA Pl3Kα historically appeared as the major PI3K isoform involved in insulin-mediated glucose metabolism, emerging evidence has demonstrated the contribution of other PI3K isoforms. In this review, we focus on the prototypical insulin receptor-PI3K pathway and on the effects of its impairment on metabolism, insulin sensitivity and the molecular pathophysiology of diabetes mellitus.

Keywords: diabetes; insulin; phosphoinositide 3-kinase

Document Type: Research article

DOI: http://dx.doi.org/10.1586/eem.09.19

Affiliations: 1: Molecular Biotechnology Center, Via Nizza 52, 10126 Turin, Italy., Email: braccini.laura@hotmail.it

Publication date: 2009-07-01

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Expert Review of Endocrinology & Metabolism provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology
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