Tyrosine kinase receptors are crucial for normal β-cell development and function

Authors: Arnaud-Dabernat, Sandrine; Sarvetnick, Nora

Source: Expert Review of Endocrinology and Metabolism, Volume 2, Number 2, March 2007 , pp. 175-183(9)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

Signaling pathways play critical roles in most physiological and pathological processes and convert an extracellular stimulus into a change of function in the recipient cell. Intracellular messages originate from the activation of membrane receptors by a variety of ligands, such as hormones, nutrients or growth factors. The receptors subsequently interact with specific intracellular cascades, triggering the phosphorylation of cell effectors. In the pancreas, these processes control the organogenesis, maintenance and function of endocrine cells within the islets. Growth factors acting through tyrosine kinase receptors play a prominent role among the multitude of signaling pathways active in pancreatic β cells. Deregulation of these processes leads to the development of disorders such as hypoglycemia or diabetes. This review will describe recent advances made on the understanding of the roles of major tyrosine kinase receptors in pancreatic β-cell physiology.

Keywords: β cell; growth factor; insulin secretion; pancreas development; tyrosine kinase receptor

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17446651.2.2.175

Publication date: 2007-03-01

More about this publication?

Expert Review of Endocrinology & Metabolism provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
Free Trials
ingentaconnect is not responsible for the content or availability of external websites

Tyrosine kinase receptors are crucial for normal β-cell development and function

Buy & download fulltext article:

Tools

Key

Text size:

Useful pages