Endocrine and inflammatory alterations in post-traumatic stress disorder

Authors: Wessa, Michèle; Rohleder, Nicolas

Source: Expert Review of Endocrinology and Metabolism, Volume 2, Number 1, January 2007 , pp. 91-122(32)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

Post-traumatic stress disorder has frequently been found associated with alterations in endogenous stress hormone systems, for example the hypothalamus-pituitary-adrenal axis and sympatho-adrenal-medullary system. Hormonal alterations are observed at the central and peripheral level of the central nervous system, and in the periphery for inflammatory disinhibition. Both consequences bear significant hazards for the individual, the former by sustaining or exacerbating the psychiatric condition, the latter by its detrimental effects on somatic health. However, the role of hormonal modifications in the development and maintenance of post-traumatic stress disorder symptoms and in the accompanying cognitive and emotional impairments still remains quite unclear.

Keywords: post-traumatic stress disorder; PTSD; trauma; hypothalamus-pituitary-adrenal axis; cortisol; sympatho-adrenal-medullary system; norepinephrine; epinephrine; inflammatory cytokines; stress reactivity

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17446651.2.1.91

Publication date: 2007-01-01

More about this publication?

Expert Review of Endocrinology & Metabolism provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
Free Trials
ingentaconnect is not responsible for the content or availability of external websites