Alternate mRNA processing of the hepatocyte nuclear factor genes and its role in monogenic diabetes

Author: Harries, Lorna W

Source: Expert Review of Endocrinology and Metabolism, Volume 1, Number 6, November 2006 , pp. 715-726(12)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

Variation in mRNA processing has the capacity to exert fine control over gene expression in most cell types. The hepatic nuclear factor genes, like approximately 74% of the genome, produce multiple transcripts. Hepatic nuclear factor isoforms exhibit both spatial and temporal variation in expression. In this review, the known isoforms of the hepatocyte nuclear factor-1α, hepatocyte nuclear factor-1β and hepatocyte nuclear factor-4α genes are described and their properties are compared. Finally, data are discussed regarding the influence of hepatocyte nuclear factor-1α alternate mRNA processing on the clinical phenotype of maturity-onset diabetes of the young.

Keywords: genotype-phenotype relationship; HNF1A; HNF1B; HNF4A; maturity-onset diabetes of the young; mRNA processing; spatial regulation; temporal regulation

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17446651.1.6.715

Publication date: 2006-11-01

More about this publication?

Expert Review of Endocrinology & Metabolism provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
Free Trials
ingentaconnect is not responsible for the content or availability of external websites