Basal cell carcinomas: molecular abnormalities and molecularly targeted therapies

Authors: Dummer, Reinhard; Karpova, Maria B; Barysch, Marjam J

Source: Expert Review of Dermatology, Volume 4, Number 4, August 2009 , pp. 355-369(15)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

Basal cell carcinomas (BCCs) are the most common neoplasms in the Caucasian population. Molecular investigations in basal cell nevus syndrome (Gorlin syndrome) have identified the hedgehog signaling pathway as being affected by various mutations. Mutations in sporadic BCC also affect the hedgehog signaling pathway, especially the Ptch1 molecule. There is significant evidence from mouse models for BCC carcinogenesis and early clinical trials that the hedgehog signaling pathway is essential to promote BCC initiation and persistence, and therefore is a perfect target for molecular interventions.

Keywords: basal cell carcinoma; molecular abnormalities; non-melanoma skin cancer; targeted therapy

Document Type: Research article

DOI: http://dx.doi.org/10.1586/edm.09.30

Affiliations: 1: Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland., Email: reinhard.dummer@usz.ch

Publication date: 2009-08-01

More about this publication?

Expert Review of Dermatology provides rapid publication of commentary and analysis on the latest research and clinical advances in all areas of dermatology, and of the challenges for this diverse specialty in a new medical era.
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
Free Trials
ingentaconnect is not responsible for the content or availability of external websites