EGF receptor: role for innate immunity during wound healing in human skin

Authors: Sørensen, Ole E; Schmidtchen, Artur; Roupé, K Markus

Source: Expert Review of Dermatology, Volume 3, Number 5, October 2008 , pp. 587-593(7)

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Abstract:

The skin constitutes an innate immunity barrier against surrounding microbes. This barrier is disrupted when wounding/injury occurs. The subsequent wound healing is divided broadly into the overlapping stages of coagulation, inflammation, proliferation and tissue remodeling. The EGF receptor (EGFR) is activated after cutaneous injury. This review highlights the role of the EGFR in the innate immune defense of the cutaneous wound. Activation of the EGFR establishes one of the molecular links between injury and the subsequent neutrophil influx, expression of antimicrobial (poly)peptides and the re-establishment of the physical barrier.

Keywords: antimicrobial peptide; EGF receptor; innate immunity; neutrophil chemotaxis; wound healing

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17469872.3.5.587

Affiliations: 1: Lund University, Division of Infection Medicine, Department of Clinical Sciences, Biomedical center B14, Tornavägen 10, 221 84 Lund, Sweden and Senior Investigative Research Fellow, Division of Infection Medicine, Department of Clinical Sciences, Lund University, Tornavägen 10, 221 84 Lund, Sweden., Email: ole_e.sorensen@med.lu.se

Publication date: 2008-10-01

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Expert Review of Dermatology provides rapid publication of commentary and analysis on the latest research and clinical advances in all areas of dermatology, and of the challenges for this diverse specialty in a new medical era.
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