Anti-inflammatory dose doxycycline for the treatment of rosacea

Author: Fowler, Joseph F

Source: Expert Review of Dermatology, Volume 2, Number 5, October 2007 , pp. 523-531(9)

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Abstract:

Rosacea is a chronic inflammatory facial condition that has traditionally been treated with topical therapies, oral antibiotics or both. The use of oral antibiotics at conventional doses can lead to antimicrobial resistance, alterations in the balance of normal microflora and potentially serious side effects. Anti-inflammatory dose doxycycline is a novel approach to the treatment of rosacea that separates the anti-inflammatory effects of doxycycline from its antimicrobial properties by limiting plasma concentrations to a range below the minimal inhibitory concentrations of susceptible bacteria. This review describes the evidence supporting the use of anti-inflammatory dose doxycycline in the treatment of rosacea, explores its mechanism of action and considers its place in therapy.

Keywords: anti-inflammatory; antimicrobial resistance; doxycycline; rosacea; tetracyclines

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17469872.2.5.523

Publication date: 2007-10-01

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Expert Review of Dermatology provides rapid publication of commentary and analysis on the latest research and clinical advances in all areas of dermatology, and of the challenges for this diverse specialty in a new medical era.
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