Hair follicles and their role in skin health

Authors: Yu, Mei; Finner, Andreas; Shapiro, Jerry; Lo, Blanche; Barekatain, Armin; McElwee, Kevin J

Source: Expert Review of Dermatology, Volume 1, Number 6, December 2006 , pp. 855-871(17)

Publisher: Expert Reviews

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Abstract:

Hair follicles produce hair fibers in a regular cycle. As part of their hair-producing role, hair follicles retain stem cells, promote cell growth and tissue invasion and induce angiogenesis. However, hair follicle function involves more than just hair fiber production. Hair follicles interact closely with the skin immune and neuroendocrine systems, supporting immunosurveilance against pathogens and aiding sensory perception. Hair follicles can also assist in wound healing and skin repigmentation. However, the unique properties of hair follicles can also be detrimental to skin health. Perhaps most significantly, hair follicles may contribute to the development of skin neoplasias. This article reviews the potential role of hair follicles in skin health.

Keywords: hair disorder; hair follicle; skin cancer; skin disease; skin immunology; stem cells

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17469872.1.6.855

Publication date: 2006-12-01

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