IngentaConnect Calcipotriene/betamethasone dipropionate: a new topical ointment ...

Author: Guenther, Lyn C

Source: Expert Review of Dermatology, Volume 1, Number 6, December 2006 , pp. 791-797(7)

Abstract:

Topical steroids and calcipotriene are the mainstay of treatment for mild-to-moderate psoriasis. They are used as monotherapy or in combination in an a.m./p.m. regimen owing to drug incompatibility. Recently, the US FDA approved a once-daily stable two-compound ointment containing calcipotriene and betamethasone dipropionate (Taclonex^®). This product has been marketed in other countries under the names Dovobet^® and Daivobet^®. It is convenient with a faster speed of onset and greater efficacy than its individual ingredients or tacalcitol. After 4 weeks of therapy, the psoriasis area and severity index is reduced by approximately 70% and half of the patients have absent or very mild disease. Furthermore, more than half of the patients reach PASI-75 after 4 weeks of treatment. The calcipotriene/betamethasone dipropionate ointment is well tolerated with a safety profile similar to betamethasone dipropionate. It is associated with 50 and 75% fewer cutaneous adverse events than calcipotriene and tacalcitol, respectively.

Keywords: betamethasone dipropionate; calcipotriene; calcipotriol; fixed combination; psoriasis

Document Type: Research article

DOI: 10.1586/17469872.1.6.791

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Calcipotriene/betamethasone dipropionate: a new topical ointment for psoriasis