Azelaic acid 15% gel for treatment of rosacea

Author: Elewski, Boni E

Source: Expert Review of Dermatology, Volume 1, Number 4, August 2006 , pp. 535-545(11)

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Abstract:

Although the pathophysiology of rosacea has not been completely elucidated, this chronic, relapsing dermatosis appears to be caused in part by the release of proinflammatory mediators from neutrophils. The effectiveness of some interventions, including topical azelaic acid and metronidazole, may be related to their anti-inflammatory activity. A 15% gel formulation of azelaic acid (Finacea^® 15% Gel), with improved pharmacological properties compared with an older azelaic acid 20% cream, has been shown to reduce erythema and inflammatory lesions in rosacea. Topical azelaic acid 15% gel was found to be more effective but transiently more irritating than topical metronidazole 0.75% gel in moderate papulopustular rosacea. Newer agents such as azelaic acid 15% gel provide physicians and patients with an expanded range of treatment options.

Keywords: azelaic acid; erythema; gel; metronidazole; papulopustular; rosacea

Document Type: Research article

DOI: http://dx.doi.org/10.1586/17469872.1.4.535

Publication date: 2006-08-01

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Expert Review of Dermatology provides rapid publication of commentary and analysis on the latest research and clinical advances in all areas of dermatology, and of the challenges for this diverse specialty in a new medical era.
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