Role of the pulmonary epithelium and inflammatory signals in acute lung injury

Author: Manicone, Anne M

Source: Expert Review of Clinical Immunology, Volume 5, Number 1, January 2009 , pp. 63-75(13)

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Abstract:

Acute lung injury (ALI) is a clinical disease marked by respiratory failure due to disruption of the epithelial and endothelial barrier, flooding of the alveolar compartment with protein-rich fluid and recruitment of neutrophils into the alveolar space. ALI affects approximately 200,000 patients annually in the USA and results in approximately 75,000 deaths. It is associated with prolonged mechanical ventilation, intensive medical care, high morbidity and mortality, and rising healthcare costs. Owing to its impact on public health, great strides have been made towards understanding the pathobiology of ALI to affect outcome. This review will focus on the role of the epithelial cell in the pathogenesis and resolution of ALI and the role of various inflammatory mediators in ALI.

Keywords: β2-agonist; acute lung injury; acute respiratory distress syndrome; chemokine; cytokine; epithelial cell; inflammation; methylprednisolone; neutrophil; salbutamol; steroid; ventilator-induced lung injury

Document Type: Research article

DOI: http://dx.doi.org/10.1586/1744666X.5.1.63

Affiliations: 1: Center for Lung Biology, 815 Mercer Street, Box 358050, Seattle, WA 98115, USA., Email: manicone@u.washington.edu

Publication date: 2009-01-01

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Expert Review of Clinical Immunology provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in disease states with a strong immunologic component, such as allergic asthma, rheumatoid arthritis, inflammatory bowel disease, psoriasis and multiple sclerosis
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