Innate immunity to influenza virus: implications for future therapy

Authors: White, Mitchell R; Doss, Mona; Boland, Patrick; Tecle, Tesfaldet; Hartshorn, Kevan L

Source: Expert Review of Clinical Immunology, Volume 4, Number 4, July 2008 , pp. 497-514(18)

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Abstract:

Innate immunity is critical in the early containment of influenza virus infection. The innate response is surprisingly complex. A variety of soluble innate inhibitors in respiratory secretions provide an initial barrier to infection. Dendritic cells, phagocytes and natural killer cells mediate viral clearance and promote further innate and adaptive responses. Toll-like receptors 3 and 7 and cytoplasmic RNA sensors are critical for activating these responses. In general, the innate response restricts viral replication without injuring the lung; however, the 1918 pandemic and H5N1 strains cause more profound, possibly harmful, innate responses. In this review, we discuss the implications of burgeoning knowledge of innate immunity for therapy of influenza.

Keywords: collectin; defensin; influenza; innate immunity; Toll-like receptor

Document Type: Research article

DOI: http://dx.doi.org/10.1586/1744666X.4.4.497

Affiliations: 1: Boston University School of Medicine, Department of Medicine, EBRC 414, 650 Albany Street, Boston, MA, USA., Email: mitchw@bu.edu

Publication date: 2008-07-01

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Expert Review of Clinical Immunology provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in disease states with a strong immunologic component, such as allergic asthma, rheumatoid arthritis, inflammatory bowel disease, psoriasis and multiple sclerosis
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