Autoimmunity and mast cell-related diseases

Authors: Reinstein, Eyal; Mekori, Yoseph A; Mor, Adam

Source: Expert Review of Clinical Immunology, Volume 4, Number 2, March 2008 , pp. 267-274(8)

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Abstract:

Allergy and autoimmunity are complex inflammatory processes caused by dysregulation of the immune system. There are select situations in which allergy and autoimmunity coexist pathologically. Traditionally considered unrelated, recent evidence suggests unexpected roles for allergic mediators in several autoimmune diseases. This review presents updated evidence for allergic mediators in several autoimmune diseases, as well as autoimmune phenomena in mast cell-related conditions. We will describe the concomitant manifestation of these conditions in patients and in animal models. The involvement of the main effectors of the immune system mast cells, T lymphocytes, antibodies and cytokines in both conditions is also discussed.

Keywords: allergy; antibody; autoimmunity; inflammation; mast cell; T lymphocyte

Document Type: Research article

DOI: http://dx.doi.org/10.1586/1744666X.4.2.267

Affiliations: 1: Instructor of Medicine, Department of Medicine B, Meir General Hospital, Kfar-Saba, 44281, Israel and, The Sackler School of Medicine, Tel-Aviv University, Israel., Email: eyalre@post.tau.ac.il

Publication date: 2008-03-01

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Expert Review of Clinical Immunology provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in disease states with a strong immunologic component, such as allergic asthma, rheumatoid arthritis, inflammatory bowel disease, psoriasis and multiple sclerosis
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