Functional dichotomy of NK cells in organ transplantation

Authors: Tha-In, Thanyalak; Luo, Shiqiao; Bushell, Andrew R; Wood, Kathryn J

Source: Expert Review of Clinical Immunology, Volume 3, Number 3, May 2007 , pp. 261-266(6)

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Abstract:

Evaluation of: Yu G, Xu X, Vu MD, Kilpatrick ED, Li XC. NK cells promote transplant tolerance by killing donor antigen-presenting cells. J. Exp. Med. 203, 1851-1858 (2006).

Natural killer (NK) cells have the potential to display different functional activities after transplantation. The traditional view is that NK cells have the capacity to contribute to rejection by facilitating the activation/differentiation of leukocytes that destroy the graft. By contrast, in the article under review, a novel role for NK cells was identified in the setting of costimulation blockade where alloreactive NK cells of recipient origin were found to have the capacity to kill donor-derived antigen-presenting cells, thereby reducing T-cell priming and promoting long-term skin graft acceptance.

Keywords: antigen-presenting cell; costimulation blockade; natural killer cell; T-cell priming; transplantation; transplant tolerance

Document Type: Research article

DOI: http://dx.doi.org/10.1586/1744666X.3.3.261

Publication date: 2007-05-01

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Expert Review of Clinical Immunology provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in disease states with a strong immunologic component, such as allergic asthma, rheumatoid arthritis, inflammatory bowel disease, psoriasis and multiple sclerosis
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