Authors: Provilus, Alfrede; Abdallah, Marie; McFarlane, Samy I

Source: Therapy, Volume 8, Number 2, March 2011 , pp. 113-120(8)

Publisher: Future Medicine

Abstract:

Diabetes has emerged as the major epidemic of modern times, with obesity, particularly central obesity, being a major risk factor for Type 2 diabetes and its attendant cardiovascular disease. Furthermore, weight reduction has been shown to prevent Type 2 diabetes in people with prediabetes and to improve glycemic control and reduce cardiovascular disease risk in the diabetic population. Weight gain is a major problem that faces physicians striving to achieve adequate glycemic, blood pressure and lipid control for their diabetic patients. The use of antidiabetic agents, particularly insulin, insulin secretagogs and thiazolidinediones, has long been associated with weight gain, not only complicating the management of diabetes but also sending mixed messages to patients who are being asked to lose weight. This article presents the effects of antidiabetic medications on bodyweight, explaining the potential mechanisms of weight gain and also discusses the available therapeutic options that could achieve better glycemic control without adverse effects on bodyweight or, even better, cause weight loss.

Keywords: antidiabetic medications; insulin; sulfonylurea; thiazolidinedione; weight gain

Document Type: Research article

DOI: http://dx.doi.org/10.2217/thy.11.8

Affiliations: 1: 1Division of Endocrinology, Medical Director of Clinical Research, College of Medicine, State University of New York -- Downstate Medical Center, 450 Clarkson Avenue, Box 50, Brooklyn, New York, 11203, USA

Publication date: 2011-03-01

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