Comparison of HapMap data on Affymetrix and Illumina platforms: expanding the power of studies and a not so unexpected synergy

Author: Dobrin, Seth

Source: Pharmacogenomics, Volume 8, Number 2, February 2007 , pp. 199-201(3)

Buy & download fulltext article:

Price: $63.00 plus tax (Refund Policy)

Abstract:

<bold>Pe'er I, de Bakker PIW, Maller J, Yelensky R, Altshuler D, Daly MJ: Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat. Genet. 38(6), 663-667 (2006)</bold> <xref rid="ref-1" ref-type="bibr">[1]</xref>. This study compares and contrasts three different high-density single nucleotide polymorphism genotyping platforms using data generated on the 270 HapMap samples. The differences in minor allele frequencies are evaluated, coverage across the entire genome using r² and then the coverage of the ENCyclopedia Of DNA Elements (ENCODE) regions is compared using both a single- and multi-point evaluation. All of these analyses are carried out on the three HapMap populations.

Document Type: Research article

DOI: http://dx.doi.org/10.2217/14622416.8.2.199

Affiliations: 1: Monsanto Company, High-Throughput Genetics, 3302 SE Convenience Boulevard, Ankeny, IA 50021, USA., Email: seth.dobrin@monsanto.com

Publication date: 2007-02-01

More about this publication?

Pharmacogenomics provides the community with an essential resource for keeping abreast of the latest developments in new pharmacogenomic initiatives, emerging technologies for accessing genomic information and the development of novel diagnostic products and strategies.
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
E-Access Trials
ingentaconnect is not responsible for the content or availability of external websites