Viral protein apoptin as a molecular tool and therapeutic bullet: implications for cancer control

Authors: Visser, Astrid E; Backendorf, Claude; Noteborn, Mathieu

Source: Future Virology, Volume 2, Number 5, September 2007 , pp. 519-527(9)

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Abstract:

The chicken anemia virus-derived protein apoptin induces apoptosis in human tumor cells via a p53-independent pathway, while leaving normal cells intact. Moreover, apoptin treatment in preclinical animal studies leads to reduced tumor growth or remission without a detectable effect on healthy tissues. Apoptin is activated by a still unknown tumor-specific kinase activity. The mode of action of apoptin is under intense investigation, as certain features make it a promising tool for discovering early events in tumorigenesis, identifying druggable targets for antitumor treatment and possibly serving as an antitumor therapy in itself.

Keywords: anaphase-promoting complex; anticancer therapy; apoptin; apoptosis; cancer; ceramide; chicken anemia virus; drug targets; pathway discovery

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460794.2.5.519

Publication date: 2007-09-01

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Future Virology provides an interdisciplinary forum for all scientists working in the fields of virology and genomic research. The journal delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research.
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