Author: Mühlberger, Elke

Source: Future Virology, Volume 2, Number 2, March 2007 , pp. 205-215(11)

Publisher: Future Medicine

Abstract:

The highly pathogenic filoviruses, Marburg and Ebola virus, belong to the nonsegmented negative-sense RNA viruses of the order Mononegavirales. The mode of replication and transcription is similar for these viruses. On one hand, the negative-sense RNA genome serves as a template for replication, to generate progeny genomes, and, on the other hand, for transcription, to produce mRNAs. Despite the similarities in the replication/transcription strategy, filoviruses have evolved structural and functional properties that are unique among the nonsegmented negative-sense RNA viruses. Moreover, there are also striking differences in the replication and transcription mechanisms of Marburg and Ebola virus. This includes nucleocapsid formation, the structure of the genomic replication promoter, the protein requirement for transcription and the use of mRNA editing. In this article, the current knowledge of the replication and transcription strategy of Marburg and Ebola virus is reviewed, with focus on the observed differences.

Keywords: ebola virus; hemorrhagic fever; marburg virus; nonsegmented negative-sense RNA viruses; nucleocapsid complex; replication; reverse genetics; transcription

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460794.2.2.205

Publication date: 2007-03-01

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• Future Virology provides an interdisciplinary forum for all scientists working in the fields of virology and genomic research. The journal delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research.
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