IngentaConnect Entecavir: a new treatment for chronic hepatitis B infection

Authors: Schreibman, Ian R; Schiff, Eugene R

Source: Future Virology, Volume 1, Number 5, September 2006 , pp. 541-552(12)

Abstract:

Hepatitis B virus can cause both acute and chronic liver disease in humans. Entecavir, a new, potent, orally administered guanosine analog for the treatment of chronic hepatitis B, has recently approved in the USA and Europe. Monotherapy with entecavir in nucleoside-naive patients has been associated with statistically superior histological improvement, greater reduction in hepatitis B virus-DNA levels, and improved normalization of alanine aminotransferase levels when compared with lamivudine. After 2 years of treatment, viral resistance to entecavir has not developed in the antiviral-naive patient population. Similar findings in terms of efficacy have also been observed in patients with lamivudine-resistant hepatitis B virus. The use of entecavir in the lamivudine-resistant patient population could lead to the development of entecavir-resistant mutants at the rate of 9% by 2 years. Entecavir is well tolerated with a good safety profile and should be considered as primary therapy for chronic hepatitis B. Entecavir may also be considered for use in the lamivudine-resistant patient at twice the dose recommended for nucleoside-naive patients, with the recognition that virologic breakthrough could develop.

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$73.00 plus tax Refund Policy