Immune evasion by poxviruses

Authors: McFadden, Grant; Nazarian, Steven H

Source: Future Virology, Volume 1, Number 1, January 2006 , pp. 123-132(10)

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Abstract:

Through eons of co-evolution, poxviruses and their hosts have come to an elegant point of equilibrium whereby the host immune system is systematically modulated in favor of the virus. Owing to the large coding capacity of poxviruses, many gene products are dedicated as virulence factors. Key targets of these immunomodulators include mediators of inflammation, chemotaxis, apoptosis and the antiviral state. It is not surprising that these systems have become targets since they are crucial for mounting an effective immune response against poxviruses. The following discussion will focus on a select group of poxvirus proteins that are able to modulate particular components of the host response efficiently to ensure propagation of the virus.

Keywords: apoptosis; chemotaxis; inflammation; interferon; poxvirus

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460794.1.1.123

Publication date: 2006-01-01

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Future Virology provides an interdisciplinary forum for all scientists working in the fields of virology and genomic research. The journal delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research.
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