Evidence-based medicine and common sense: practical and ethical issues in clinical trials for osteoporosis

Author: Heaney, Robert P

Source: Future Rheumatology, Volume 2, Number 1, February 2007 , pp. 105-110(6)

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Abstract:

For ethical reasons, testing the efficacy of new treatments for chronic diseases such as osteoporosis has hit a brick wall. Furthermore, existing trial designs, although satisfying requirements for drug registration, typically produce results with limited generalizability. Compounding the problem, these results often serve as the basis for treatment guidelines, which, in turn, are assembled by policy-makers and analysts who often do not understand the biology of the systems concerned. In this perspective, the details of these problems are briefly described and the broad outlines of some solutions suggested.

Keywords: antiresorptive drugs; bone remodeling; calcium; cohort study; evidence-based medicine; fracture; osteoporosis; randomized controlled trial; nutrition; vitamin D

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460816.2.1.105

Publication date: 2007-02-01

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Future Rheumatology provides analysis and commentary on our understanding of disease mechanisms, emerging therapeutic strategies and new diagnostic approaches. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this expanding area of specialization.
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