Authors: Falcini, Fernanda; Cimaz, Rolando

Source: Future Rheumatology, Volume 1, Number 6, December 2006 , pp. 751-760(10)

Publisher: Future Medicine

Abstract:

This review reports the advances on etiopathogenesis, clinical findings, outcome and treatment of the most common pediatric vasculitis. In particular, we focus on Henoch-Schönlein purpura renal involvement, its possible prevention and therapy. Owing to the worldwide awareness of new features of Kawasaki disease, this article discusses atypical and incomplete disease. The approach to patients with persistently active disease, the role of corticosteroids and new biological agents (antitumor necrosis factor) are discussed. The two main clinical forms of polyarteritis nodosa, systemic and cutaneous, are described, and the role of Group A Streptococcus infection in triggering the cutaneous form is highlighted. The use of magnetic resonance imaging in diagnosing, monitoring and guiding the treatment of Takayasu disease, and the improvement of long-term prognosis through reconstructive surgery and transluminal angioplasty for the vascular complications are also emphasized. Finally, we have highlighted the attempt of Ozen and an international group of experts to reach a consensus on classification criteria applied for the most common pediatric vasculitides.

Keywords: Henoch-Schönlein purpura; Kawasaki disease; pediatric vasculitis; polyarteritis nodosa

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460816.1.6.751

Publication date: 2006-12-01

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• Future Rheumatology provides analysis and commentary on our understanding of disease mechanisms, emerging therapeutic strategies and new diagnostic approaches. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this expanding area of specialization.
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