Authors: Praharaj, Snigdha; Overbey, Douglas; Giblin, Michael F

Source: Future Oncology, Volume 6, Number 8, August 2010 , pp. 1325-1337(13)

Publisher: Future Medicine

Abstract:

Research is currently underway worldwide into the development of receptor-specific radiopharmaceuticals for the imaging and treatment of cancer. The successful clinical development of radiolabeled somatostatin analogs for imaging and treatment of cancers overexpressing somatostatin receptors has catalyzed further preclinical investigation of other radiolabeled peptides for molecular imaging and peptide-receptor radiotherapy, including such well-studied peptide vectors as cholecystokinin, neurotensin, bombesin and RGD peptides. Within this larger context, this article will focus on the current status of two more recent additions to the list of molecular imaging targets - guanylate cyclase C, a specific marker for colorectal cancer, and the urokinase plasminogen activator receptor, a cell-surface receptor overexpressed in diverse cancer types.

Keywords: guanylate cyclase C; molecular imaging; PET; SPECT; uroguanylin; urokinase-type plasminogen activator receptor

Document Type: Research article

DOI: http://dx.doi.org/10.2217/fon.10.91

Affiliations: 1: 1Harry S Truman Memorial Veterans' Administration Hospital, Research Service, A004, 800 Hospital Drive, Columbia, MO 6520, USA

Publication date: 2010-08-01

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• Future Oncology provides a forum for a new era of cancer care as research efforts burgeon in this challenging area. The burden of disease is set to increase in our increasingly aged populations, but the available armamentarium is also set to grow rapidly and to offer the potential to focus on individual needs. The journal focuses on the most important advances and highlights their relevance in the clinical setting.
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