Stroke in the immature brain: review of pathophysiology and animal models of pediatric stroke

Authors: Kuluz, John; Huang, Tingting; Watson, Brant; Vannucci, Susan

Source: Future Neurology, Volume 3, Number 2, March 2008 , pp. 199-216(18)

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Abstract:

Pediatric stroke research presents many challenges. Relatively low incidence, need for age stratification, diverse etiologies, delays in diagnosis, lack of an established age-based stroke severity scale and outcome measures are only some of the issues that have prevented the implementation of clinical trials in infants and children with stroke. Experimental animal models of pediatric stroke, therefore, are critical to understanding the pathophysiology and management of ischemic brain damage in the immature brain, and provide the necessary platform for future clinical trials. In this review we discuss the pertinent clinical aspects of pediatric stroke, the pathophysiology of stroke in the developing brain and the animal models established to study basic mechanisms as well as translational issues in pediatric stroke.

Keywords: brain ischemia; children; focal cerebral ischemia; pediatrics; stroke

Document Type: Research article

DOI: http://dx.doi.org/10.2217/14796708.3.2.199

Publication date: 2008-03-01

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Future Neurology provides a forum to address the most important challenges and advances in our understanding of neurological disease, and highlights emerging trends and prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson's disease.
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