Stroke in the immature brain: review of pathophysiology and animal models of pediatric stroke

Authors: Kuluz, John; Huang, Tingting; Watson, Brant; Vannucci, Susan

Source: Future Neurology, Volume 3, Number 2, March 2008 , pp. 199-216(18)

Publisher: Future Medicine

Buy & download fulltext article:

OR

Price: $73.00 plus tax (Refund Policy)

Abstract:

Pediatric stroke research presents many challenges. Relatively low incidence, need for age stratification, diverse etiologies, delays in diagnosis, lack of an established age-based stroke severity scale and outcome measures are only some of the issues that have prevented the implementation of clinical trials in infants and children with stroke. Experimental animal models of pediatric stroke, therefore, are critical to understanding the pathophysiology and management of ischemic brain damage in the immature brain, and provide the necessary platform for future clinical trials. In this review we discuss the pertinent clinical aspects of pediatric stroke, the pathophysiology of stroke in the developing brain and the animal models established to study basic mechanisms as well as translational issues in pediatric stroke.

Keywords: brain ischemia; children; focal cerebral ischemia; pediatrics; stroke

Document Type: Research article

DOI: http://dx.doi.org/10.2217/14796708.3.2.199

Publication date: 2008-03-01

More about this publication?
Related content

Tools

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page