Authors: Fiorini, Michele; Zanusso, Gianluigi; Baj, Andreina; Bertolasi, Laura; Toniolo, Antonio; Monaco, Salvatore

Source: Future Neurology, Volume 2, Number 4, July 2007 , pp. 451-463(13)

Publisher: Future Medicine

Abstract:

Post-polio syndrome (PPS) refers to a constellation of new neurological, musculoskeletal and general symptoms occurring in survivors of poliomyelitis decades after acute paralytic and nonparalytic disease. The common manifestations of PPS include generalized, central and peripheral fatigue, muscle weakness and musculoskeletal pain. The pathogenesis of PPS remains obscure. Three prevailing hypotheses have been advanced: stress-induced degeneration of surviving neurons, persistent poliovirus replication or virus reactivation and immune-mediated damage. The diagnosis of PPS is based on medical history and clinical examination, since no specific diagnostic tests are available. In the light of recent studies demonstrating a partial beneficial effect of intravenous immunoglobulin, this article will focus on cerebrospinal fluid biomarkers reflecting disease activity and pathogenic processes in PPS.

Keywords: 14-3-3 proteins; antivirals; cystatin C; cytokines; enteroviruses; fatigue; intravenous immunoglobulin; picornaviruses; post-polio syndrome; virus persistence

Document Type: Research article

DOI: http://dx.doi.org/10.2217/14796708.2.4.451

Publication date: 2007-07-01

More about this publication?

• Future Neurology provides a forum to address the most important challenges and advances in our understanding of neurological disease, and highlights emerging trends and prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson's disease.
• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Information for Advertisers
• Terms & Conditions
• Information for Librarians
• E-Access Trials
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Neurology & Psychiatry
• By this author: Fiorini, Michele ;  Zanusso, Gianluigi ;  Baj, Andreina ;  Bertolasi, Laura ;  Toniolo, Antonio ;  Monaco, Salvatore

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers