Lipid connection to bipolar disorder

Authors: Azab, Abed N; Greenberg, Miriam L

Source: Future Neurology, Volume 1, Number 4, July 2006 , pp. 505-513(9)

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Abstract:

Bipolar disorder is a severe and chronic illness affecting approximately 1.5% of the American population. Despite the availability of mood bipolarstabilizers such as lithium, valproate, carbamazepine and lamotrigine, bipolar disorder is characterized by high rates of recurrence, as treatment with these and other drugs is ineffective for and not tolerated by a significant percentage of patients. Several hypotheses have been postulated to explain the mechanism(s) of action of mood stabilizers. However, the biological and molecular bases of the disease are not fully understood, hampering the development of more effective and safer drugs. A large body of evidence associates lipids (cholesterol, phospholipids and fatty acids) with the mechanism and pathology of bipolar disorder. The purpose of this paper is to review the lipid connection to bipolar disorder.

Keywords: bipolar disorder; cholesterol; fatty acids; lithium; phospholipids; valproate

Document Type: Research article

DOI: http://dx.doi.org/10.2217/14796708.1.4.505

Publication date: 2006-07-01

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Future Neurology provides a forum to address the most important challenges and advances in our understanding of neurological disease, and highlights emerging trends and prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson's disease.
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