Communication systems in the genus Burkholderia: global regulators and targets for novel antipathogenic drugs

Authors: Sokol, Pamela A; Malott, Rebecca J; Riedel, Kathrin; Eberl, Leo

Source: Future Microbiology, Volume 2, Number 5, October 2007 , pp. 555-563(9)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

The genus Burkholderia not only contains the primary pathogens Burkholderia pseudomallei and Burkholderia mallei but also several species that have emerged as opportunistic pathogens in persons suffering from cystic fibrosis or chronic granulomatous disease and immunocompromised individuals. Burkholderia species utilize quorum-sensing (QS) systems that rely on N-acyl-homoserine lactone (AHL) signal molecules to express virulence factors and other functions in a population-density-dependent manner. Most Burkholderia species employ the CepIR QS system, which relies on N-octanoyl-homoserine lactone. However, some strains harbour multiple QS systems and produce numerous AHLs. QS systems have been demonstrated to be essential for full virulence in various infection models and, thus, these regulatory systems represent attractive targets for the development of novel therapeutics.

Keywords: biofilm; Burkholderia; cystic fibrosis; infection models; N-acyl-homoserine lactone; pathogenicity; quorum sensing

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460913.2.5.555

Publication date: 2007-10-01

More about this publication?

Future Microbiology provides cutting-edge coverage of advances our understanding of microbial organisms and corresponding treatment strategies and agents in infectious disease. The journal also addresses the molecular basis of disease, epidemiologic trends and advanced diagnostic technologies.
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
E-Access Trials
ingentaconnect is not responsible for the content or availability of external websites