Prospects for the treatment of drug-resistant malaria parasites

Authors: Tilley, Leann; Davis, Timothy ME; Bray, Patrick G

Source: Future Microbiology, Volume 1, Number 1, June 2006 , pp. 127-141(15)

Buy & download fulltext article:

Price: $73.00 plus tax (Refund Policy)

Abstract:

Widespread parasitic resistance has led to an urgent need for the development and implementation of new drugs for the treatment of Plasmodium falciparum malaria. Artemisinin and its derivatives are becoming increasingly important, used preferably in combination with a second antimalarial agent to increase the efficacy and slow the development of resistance. However, cost, production and pharmacological issues associated with artemisinin derivatives and potential partner drugs are hindering the implementation of combination therapies. This article reviews the molecular basis of the action of, and resistance to, different antimalarials and examines the prospects for the next generation of drugs to combat this potentially lethal human pathogen.

Keywords: antimalarials; artemisinin combination therapy; chloroquine; drug resistance; endoperoxide; malaria; PfCRT; quinolines

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460913.1.1.127

Affiliations: 1: Department of Biochemistry, La Trobe University, Melbourne, Victoria 3086, Australia., Email: L.Tilley@latrobe.edu.au

Publication date: 2006-06-01

More about this publication?

Future Microbiology provides cutting-edge coverage of advances our understanding of microbial organisms and corresponding treatment strategies and agents in infectious disease. The journal also addresses the molecular basis of disease, epidemiologic trends and advanced diagnostic technologies.
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Information for Advertisers
Terms & Conditions
Information for Librarians
E-Access Trials
ingentaconnect is not responsible for the content or availability of external websites