The RAGE connection to diabetes and atherosclerosis: an intertwined web of advanced glycation and inflammation

Authors: Ramasamy, Ravichandran; Yan, Shi Fang; Schmidt, Ann Marie

Source: Future Lipidology, Volume 2, Number 2, April 2007 , pp. 239-250(12)

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Abstract:

The receptor for advanced glycation end products (RAGE) transduces the impact of the products of nonenzymatic glycation and oxidation of proteins, the advanced glycation end products, proinflammatory ligands S100/calgranulins and high mobility group box 1. The ligand families of RAGE accumulate in the vasculature in diabetes and are enriched in atherosclerotic lesions, both in human and animal models. Experimentation in animal models of both Type 1 and 2 diabetes reveals that antagonism of the ligand--RAGE axis suppresses the development and progression of vascular and inflammatory cell perturbation in the diabetic milieu; key processes linked to acceleration of atherosclerosis and exaggerated neointimal expansion consequent to arterial injury. We propose that blockade of RAGE may represent an effective target for therapeutic intervention in diabetes and its cardiovascular complications.

Keywords: 3-deoxyglucosone; advanced glycation end product; atherosclerosis; diabetes; glycation; hyperglycemia; methylglyoxal; RAGE; receptors; restenosis

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460875.2.2.239

Publication date: 2007-04-01

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Future Lipidology addresses therapeutic strategies and emerging topics in this complex area of cardiovascular medicine. The journal delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum.
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