Cholesteryl ester transfer protein inhibitors: new strategies for raising high-density lipoprotein cholesterol

Authors: Mabuchi, Hiroshi; Inazu, Akihiro

Source: Future Lipidology, Volume 1, Number 4, August 2006 , pp. 487-500(14)

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Abstract:

Epidemiological studies have shown that low-density lipoprotein cholesterol (LDL-C) is a strong risk factor for coronary heart disease (CHD), whilst high-density lipoprotein cholesterol (HDL-C) reduces the risk for CHD. Therefore, strategies to manage dyslipidemia in an effort to prevent or treat CHD have primarily attempted to decrease LDL-C and raise HDL-C levels. Cholesteryl ester transfer protein (CETP) inhibitors have proven to be effective in achieving both a reduction in LDL-C and an increase in HDL-C. This review will discuss the current status and future prospects of CETP inhibitors in the treatment of CHD.

Keywords: CETP-inhibitor; cholesterol ester transfer protein; coronary heart disease; high-density lipoprotein cholesterol

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460875.1.4.487

Affiliations: 1: Kanazawa University, Graduate School of Medical Science, Department of Lipidology, Division of Medicine, Takara-machi 13-1, Kanazawa 920-8641, Japan., Email: mabuchi@med.kanazawa-u.ac.jp

Publication date: 2006-08-01

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Future Lipidology addresses therapeutic strategies and emerging topics in this complex area of cardiovascular medicine. The journal delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum.
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