Authors: Zandbergen, Fokko; van Dijk, Susan; Müller, Michael; Kersten, Sander

Source: Future Lipidology, Volume 1, Number 2, April 2006 , pp. 227-236(10)

Publisher: Future Medicine

Abstract:

Recently, several proteins with homology to angiopoietins have been discovered. Three members of this new group, designated angiopoietin-like proteins (ANGPTLs), have been linked to regulation of energy metabolism. This review will focus on the fasting-induced adipose factor (FIAF)/ANGPTL4 as an important modulator of plasma lipid metabolism. FIAF/ANGPTL4 is a direct target of the insulin-sensitizing thiazolidinediones and hypolipidemic fibrate drugs. The collective data suggests that FIAF/ANGPTL4 plays an important role in the systemic partitioning of fatty acids, especially under fasting conditions. FIAF/ANGPTL4 prevents the clearance of plasma triglycerides and appears to stimulate adipose tissue lipolysis, resulting in lipids being redirected from storage to the circulation. FIAF/ANGPTL4 thus represents an interesting candidate for therapeutic targeting of dyslipidemia. It can be hypothesized that alterations in FIAF/ANGPTL4 signaling might be involved in dyslipidemia. While the importance of FIAF/ANGPTL4 in lipoprotein metabolism is well established, the effects of FIAF/ANGPTL4 on glucose homeostasis currently remain ambiguous.

Keywords: angiogenesis; angiopoietin-like proteins; dyslipidemia; fasting-induced adipose factor; lipid metabolism; lipoprotein lipase; lipoproteins; triglyceride clearance; tumorigenesis

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17460875.1.2.227

Affiliations: 1: Cardiovascular Medicine, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, NRB 7, 742 Boston, Massachusetts 02115, USA., Email: fzanderbergen@rics.bwh.harvard.edu

Publication date: 2006-04-01

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• Future Lipidology addresses therapeutic strategies and emerging topics in this complex area of cardiovascular medicine. The journal delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum.
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