Cardiovascular risk and choice of HIV drug regimen

Author: Sabin, Caroline A

Source: Future HIV Therapy, Volume 2, Number 1, January 2008 , pp. 83-92(10)

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Abstract:

Since the introduction of combination antiretroviral therapy (cART), there have been many conflicting reports linking its use to the development of cardiovascular disease (CVD). Most antiretroviral drugs have been associated with the development of lipid abnormalities to some degree. However, whereas several large observational studies have reported a link between the use of cART (particularly protease inhibitors) and CVD, evidence linking specific antiretroviral drugs to CVD is limited. Much of the evidence linking cART to the development of dyslipidemia derives from randomized trials. However, given the relative infrequency of CVD in most HIV-positive populations, these may be inadequately powered to demonstrate a link with clinical events. In contrast, large observational studies have greater power to describe the development of clinical events but may be affected by bias. This review will describe the current literature linking cART to CVD as well as the limitations of some of the published studies.

Keywords: antiretroviral drugs; cardiovascular disease; diabetes mellitus; dyslipidemia; HAART; protease inhibitors

Document Type: Research article

DOI: http://dx.doi.org/10.2217/17469600.2.1.83

Publication date: 2008-01-01

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Future HIV Therapy keeps clinicians and researchers up to date with the significant advances that will enable us to develop new treatments to target the virus and any resistant strains that might develop, and also to improve side effects, adherence and education in therapy, and simplify drug regimens and reduce costs.
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