Future of cardiac resynchronization therapy

Authors: Arujuna, Aruna Vishnu; Ginks, Matthew; Rinaldi, Aldo

Source: Future Cardiology, Volume 4, Number 2, March 2008 , pp. 191-201(11)

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Abstract:

Cardiac resynchronization therapy (CRT) has proven to be a beneficial treatment option in patients with severe drug refractory heart failure in the presence of electromechanical dyssynchrony. More recent trials have demonstrated mortality benefits associated with CRT, and even further reductions when combined with an internal cardiac defibrillator. Addressing the 20--30% cohort of patients who do not derive benefit from this novel therapy is a rapidly emerging area of research activity with encouraging results. Here we review the CRT trial evidence that forms the basis of patient-selection guidelines for device implantation and describe the present outstanding issues, alongside identifying future trends in CRT that appear promising.

Keywords: cardiac resynchronization therapy; dyssynchrony; heart failure

Document Type: Research article

DOI: http://dx.doi.org/10.2217/14796678.4.2.191

Publication date: 2008-03-01

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Future Cardiology reflects the new era of cardiology and highlights new molecular approaches in advancing cardiovascular therapy. The journal publishes clinical research, commentary and therapeutic overviews highlighting optimal therapy and future options and strategies.
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