Effect of smoking on abdominal aortic aneurysms: novel insights through murine models

Author: Curci, John A

Source: Future Cardiology, Volume 3, Number 4, July 2007 , pp. 457-466(10)

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Abstract:

Abdominal aortic aneurysm is a poorly understood and fatal disease. The etiology of the disease is believed to be multifactorial. Of all the recognized clinical associations, none has a greater impact on the incidence and progression of the disease than exposure to tobacco smoke. Novel murine models developed over the past several years present the opportunity to investigate the mechanism of this critical clinical relationship.

Keywords: abdominal aorta; aneurysm; emphysema; inflammation; mechanism; metalloproteinases; smoking; tobacco

Document Type: Research article

DOI: http://dx.doi.org/10.2217/14796678.3.4.457

Publication date: 2007-07-01

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Future Cardiology reflects the new era of cardiology and highlights new molecular approaches in advancing cardiovascular therapy. The journal publishes clinical research, commentary and therapeutic overviews highlighting optimal therapy and future options and strategies.
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