Mechanical and pharmacological methods to prevent venous thromboembolism

Author: Bergqvist, David

Source: Future Cardiology, Volume 3, Number 2, March 2007 , pp. 213-224(12)

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Abstract:

Today, it is possible to define certain risk groups for the development of venous thromboembolism, most studies having been conducted on post-operative venous thromboembolism. Nonetheless, the risk classification is rather inexact, resulting in many patients receiving prophylaxis who would not have gone on to develop the complication. However, the current prophylactic methods are safe and can therefore also be used in the post-operative situation. The dominating pharmacological substances are unfractionated heparin, low-molecular-weight heparins and the pentasaccharide fondaparinux. In some situations (such as elective hip surgery and likely hip fracture surgery, and in many cases where malignant diseases in the abdomen/pelvis have been operated upon), extended prophylaxis for 1 month should be considered.

Keywords: deep vein thrombosis; fondaparinux; heparin; low-molecular-weight heparin; mechanical methods; prophylaxis; pulmonary embolism; surgery; venous thromboembolism

Document Type: Research article

DOI: http://dx.doi.org/10.2217/14796678.3.2.213

Publication date: 2007-03-01

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Future Cardiology reflects the new era of cardiology and highlights new molecular approaches in advancing cardiovascular therapy. The journal publishes clinical research, commentary and therapeutic overviews highlighting optimal therapy and future options and strategies.
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