Authors: Tantry, Udaya S; Etherington, Amena; Bliden, Kevin P; Gurbel, Paul A

Source: Future Cardiology, Volume 2, Number 3, May 2006 , pp. 343-366(24)

Publisher: Future Medicine

Abstract:

Pharmacological management of thrombotic complications is strongly influenced by antiplatelet treatment strategies. Recent clinical trials have clearly indicated that current antiplatelet strategies may not inhibit recurrent thrombotic events in selected patients and improvement is necessary. Recently, there has been a gradual modification in the guidelines for clopidogrel dosing. In addition, newly developed P2Y₁₂ receptor inhibitors and thrombin inhibitors are undergoing Phase II and III clinical trials. Moreover, research related to novel agents that interfere with other steps in coagulation and platelet adhesion, and platelet thromboxane and thrombin receptor blockers, show promise. An important future step will probably be the development of personalized therapy based on defining the individual patient's propensity for thrombosis through investigation of platelet–thrombin–fibrin interactions. Such an approach will enhance the targeting of specific therapy based on the pathophysiology of the individual patient.

Keywords: antiplatelet agents; aspirin; GP IIb/IIIa inhibitors; P2Y12 receptor blockers; platelet–thrombin–fibrin interaction; thrombin inhibitors

Document Type: Research article

DOI: http://dx.doi.org/10.2217/14796678.2.3.343

Publication date: 2006-05-01

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• Future Cardiology reflects the new era of cardiology and highlights new molecular approaches in advancing cardiovascular therapy. The journal publishes clinical research, commentary and therapeutic overviews highlighting optimal therapy and future options and strategies.
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